Laureaten van de projectoproep "Wetenschappelijke Grants 2024”
In het kader van haar 100ste verjaardag en dankzij de vrijgevigheid van haar donateurs heeft Stichting tegen Kanker een uitzonderlijk bedrag van bijna 35 miljoen euro toegekend om 68 oncologische onderzoeksprojecten te financieren.
Deze innovatieve projecten hebben tot doel een beter inzicht te krijgen in de ziekte, het genezingspercentage te verhogen en de levenskwaliteit van mensen met kanker te verbeteren.
De winnaars zijn geselecteerd door onafhankelijke wetenschappelijke raadsleden:
Fundamenteel onderzoek: 42 projecten - € 21 015 359
Onderzoeks-
team(s)
team(s)
Organisatie(s)
Bedrag
Kankertype
Behandelings-
type
type
Projecttitel
Aerts Stein
KU Leuven
600.000 €
Hersenen
Modeling and synthetic design of transcriptional enhancers to target cell states in glioblastoma and its microenvironment
Alsteens David
UCLouvain
336.000 €
Borst
Immuuntherapie
The Role of Sialylation in Cancer-Macrophage Interactions: Impact CD169 Context-Dependent Signalling
Amant Frédéric
KU Leuven
479.939 €
Chimiothérapie
Treating pregnant cancer patients with chemotherapy causes a persistent mutagenic imprint in the offsprings blood? (IMPRINT)
Bergers Gabriele
KU Leuven
480.000 €
Immuuntherapie
Hemorrhage-induced HO-1 macrophages infer resistance to antiangiogenic immunotherapies in cancer
Berx Geert
Universiteit Gent
477.309 €
Colorectaal
Immuuntherapie
Plasticity controlled colon cancer initiation and progression
Blanpain Cédric
Université Libre de Bruxelles
600.000 €
Huid
Mechanisms leading to the elimination of looser cells by cell competition during tumor initiation
Blomme Arnaud
Université de Liège
480.000 €
Long
Lipotranslate - Targeting lipid-induced mRNA translation reprogramming as a strategy to improve therapy in lung cancer
Chariot Alain
Université de Liège
480.000 €
Lever
Translational reprogramming through tRNA modifications in cancer
Close Pierre
Université de Liège
480.000 €
Immuuntherapie
tRNA epitranscriptomics: a new vulnerability in cancer
De Keersmaecker Kim
KU Leuven
600.000 €
Leukemie
Traitement ciblé
Ribosomal protein mutations in cancer: diversity in oncogenic mechanisms
De Preter Katleen
Universiteit Gent
430.368 €
Neuroblastoma
Tracking cfDNA origin during therapy in barcoded cancer models
De Wever Olivier
Universiteit Gent
480.000 €
Eierstok
Gerichte behandeling
Impact of MEK targeted therapy on cancer-associated fibroblast state and consequential effects for cancer progression
Feron Olivier
UCLouvain
480.000 €
Chemotherapie
Nexus between Tumor Acidosis and Drug Tolerant Persister Cells
Fuks François
Université Libre de Bruxelles
589.000 €
Borst
Role of the connection between epigenetics and epitranscriptomics in breast cancer
Guilliams Martin & Vermeulen Peter
Universiteit Gent & GZA Ziekenhuizen Sint Augustinus
600.000 €
Lever
MeTAMorphosis
Halder Georg
KU Leuven
600.000 €
Lever
Gecombineerde behandelingen
Suppressing mechano-induced resistance to Ras/MAPK pathway inhibitors by combinatorial treatment with TEAD inhibitors
Hendrix An
Universiteit Gent
480.000 €
Borst
Immuuntherapie
Targeting Rab27b-mediated release of extracellular vesicles to suppress cancer progression and elicit cGAS-mediated anti-cancer immunity
Hennequart Marc
UNamur
480.000 €
Pancreas
Gerichte behandeling
Harnessing the metabolic switch that occurs in early pancreatic cancer events for therapy and detection
Herfs Michael
Université de Liège
464.000 €
Huid
Immuuntherapie & Radiotherapie
Deciphering the hijacking of host DNA damage/repair mechanisms by Merkel cell polyomavirus and its associated critical vulnerabilities
Janssens Sophie
Universiteit Gent
480.000 €
Immuuntherapie & Chemotherapie
Immunogenic cell death from a dendritic cell perspective, some old concepts revisited
Lambrecht Bart
Universiteit Gent
475.696 €
Long
Immuuntherapie
Type 2 inflammation in lung cancer
Lambrechts Diether
KU Leuven
660.000 €
Immuuntherapie
Deciphering the tumor antigen landscape of CD4+ T-cells during checkpoint immunotherapy
Leucci Eleonora
KU Leuven
600.000 €
Huid
Immuuntherapie
Characterisation of a novel immune checkpoint peptide
Lucas Sophie
Institut de Duve
600.000 €
Immuuntherapie
Understanding the mechanisms underpinning the immunotherapeutic activity of GARP:TGF-β1 blockade in cancer
Mazzone Massimiliano
KU Leuven
720.000 €
Borst
Immuuntherapie
Epigenetic regulation as a main instructor guiding tumor-associated macrophage phenotypes: can we revert the trend?
Menu Eline
Vrije Universiteit Brussel
428.000 €
Multipel myeloma
Immuuntherapie
Elucidating immune suppressive mechanisms against CAR T therapy
Ntziachristos Panagiotis
Universiteit Gent
600.000 €
Leukemie
RNA methylation controls oncogenic transcription and metabolism in T-cell leukemia
Rapino Francesca
Université de Liège
476.000 €
tRNA dynamics shapes intestinal cancer stem cell phenotypes.
Remsik Jan
KU Leuven
480.000 €
Hersenen
Immuuntherapie
Untangling the interactome of dendritic cells in leptomeningeal metastasis
Scheele Colinda
KU Leuven
454.356 €
Borst
Deconstructing the dynamic interplay between mutant cells and their environment as a driver of mammary tumor initiation
Swinnen Johannes
KU Leuven
360.000 €
Pancreas
Immuuntherapie
Immunolipidomics: targeting lipid antigens to combat pancreatic cancer
Taghon Tom
Universiteit Gent
478.233 €
Immuuntherapie
Using spatial transcriptomics to identify the molecular drivers of human γδ subset development for tailored cancer immunotherapy
Tarabichi Maxime
Université Libre de Bruxelles
300.692 €
Schildklier
The somatic evolution of the thyroid: retracing the path to cancer in vivo
Tejpar Sabine
KU Leuven
476.800 €
Colorectaal
Immuuntherapie
Understanding and combatting niches of inflammation and antigenicity as immune-surveillance strategies in colorectal cancer
Van den Eynde Benoit
Institut de Duve
480.000 €
Immuuntherapie
The role of Integrated Stress Response in modulating immune cells in the tumor microenvironment
Vandesompele Jo
Universiteit Gent
480.000 €
Neuroblastoma
Traitement ciblé
Study of acquired resistance and recurrence through multi-omics spatial analysis of neuroblastoma
van Gastel Nick
Institut de Duve
480.000 €
Leukemie
Targeting metabolic niche support to eliminate residual leukemic stem cells
Van Ginderachter Jo
Vrije Universiteit Brussel
469.056 €
Long
Lung cancer-induced alterations in the bone marrow progenitor and monocyte compartment with implications for tumor-associated and healthy tissue macrophages
Vereecke Lars
Universiteit Gent
580.000 €
Colorectaal
Immuuntherapie
Microbial drivers of colorectal cancer development and therapy
Voet Thierry & Piessevaux Hubert
KU Leuven & UCLouvain
479.910 €
Colorectaal
Bridging biology to histology through spatially informed assays in early colorectal cancer: towards clinical pathology 2.0
Willems Luc
Université de Liège
360.000 €
Leukemie
The HTLV-1 retrovirus subverts the HLTF antiviral restriction factor to induce adult T-cell leukemia
Zhu Jingjing
Institut de Duve
480.000 €
Immuuntherapie
α2-Adrenergic Receptor Agonists in Cancer Immunotherapy: Unraveling the Mechanisms of Action
Translationeel en klinisch onderzoek: 26 projecten -
€ 13 899 679
Onderzoeks-
team(s)
team(s)
Organisatie(s)
Bedrag
Kankertype
Behandelings-
type
type
Projecttitel
Albersen Maarten
UZ Leuven
547.500 €
Génito-urinaire
Immuuntherapie & Chemotherapie
Advancing Penile, Vulvar and Urethral Squamous Cell Carcinoma management by identifying tissue and blood-based signals for immunochemotherapy response
Amant Frédéric
KU Leuven
350.000 €
Urogenitaal
Optimization of Staging and Treatment in Pregnant Patients with Cervical Cancer
Berghmans Thierry
Institut Jules Bordet
548.322 €
Long
Immuuntherapie
Fibroblast activation protein targeted radioligand therapy as potential inverter of the immune escape mechanism of non-small cell lung cancers (FAP-Lu-ng)
Beuselinck Benoit
KU Leuven
400.000 €
Nier
Immuuntherapie
Translational biomarker research in metastatic renal cell carcinoma treated with immune checkpoint inhibitors and/or angiogenesis inhibitors
Buisseret Laurence
Institut Jules Bordet
596.000 €
Borst
Immuuntherapie & Radiotherapie
Immune priming of the tumor microenvironment in Luminal B Breast Cancer
Cataldo Didier
Université de Liège
300.000 €
Long
Immuuntherapie
Effects of Air Pollution on the Recruitment of PolyMorphonuclear Myeloid-Derived Suppressor Cells (PMN-MDSCs) into the Lung Parenchyma and consequences of PMN-MDSCs on the efficacy of treatments by immune checkpoints inhibitors
De Keersmaecker Kim
KU Leuven
600.000 €
Lymphoma
Traitements combinés
Sertraline combination therapy for T-cell malignancies: Mode of action and preclinical optimization
Demeulemeester Jonas
KU Leuven
485.000 €
Sarcoma
AGENDAS – Advanced Genomics for Sarcoma Diagnosis and Care
Deroose Christophe
UZ Leuven
593.176 €
Multipel myeloma
First-in-man and phase 2 study in multiple myeloma patients of [18F]F-AlF-NOTA-SC, a fluorine-18 labeled PET tracer for CXCR4.
Devoogdt Nick
Vrije Universiteit Brussel
596.000 €
Immuuntherapie
CHOPIN: CD8 lympHOcyte PET Imaging with a Nanobody tracer
Fuks François
Université Libre de Bruxelles
582.000 €
Leukemie
Gecombineerde behandelingen
Innovative combination of epigenetic drugs: toward a new treatment approach to cure leukemia
Halder Georg
KU Leuven
392.000 €
Lever
Gerichte behandeling
Attacking cholangiocarcinoma with driver-specific inhibitor combinations
Kerre Tessa
Universiteit Gent
592.000 €
Leukemie
Gerichte behandeling
Drug response profiling of adult T-ALL to optimize salvage therapeutic strategies for refractory/relapsed patients
Lambrechts Diether & Lentacker Ine
KU Leuven & Universiteit Gent
720.000 €
Lever
Immuuntherapie
Development and clinical validation of a personalized mRNA-based cancer vaccine for patients with advanced hepatocellular carcinoma
Laurent Sophie
Université de Mons
450.000 €
Hoofd en hals
Theranostiek
Development of a novel theranostic boron-containing nanovector to enhance Boron Neutron Capture Therapy effectiveness in head and neck cancers
Leucci Eleonora
KU Leuven
660.000 €
Huid
Immuuntherapie
An RNA-based strategy to overcome resistance to immune checkpoint blockade
Marine Jean-Christophe
KU Leuven
600.000 €
Huid
Immuuntherapie
PreCision immUnotheRapy (CURe)
Moens Maarten
Vrije Universiteit Brussel
599.605 €
Intrathecal drug delivery systems versus comprehensive medical management for severe cancer pain: a randomized controlled trial
Offner Fritz
Universiteit Gent
289.724 €
Lymphoma
Gerichte behandelingen
Finetuning a CD70 targeted nanoCAR Therapy for late stage Cutaneous T Cell Lymphoma
Smits Evelien
Universiteit Antwerpen
584.000 €
Hersenen
Gerichte behandelingen
An immunometabolic approach to pediatric and adult high-grade glioma: preclinical optimization of CAR-NK cell therapy with ketogenic diet
Thienpont Bernard
KU Leuven
527.000 €
Uveal melanoom
DetectUM
Vandamme Timon
UZ Antwerpen
598.000 €
Neuroendocriene
1000 NEN genome
Vandekerckhove Bart
UZ Gent
600.000 €
Long
Immuuntherapie
Safety and feasibility study of GALSOME-NEO, a personalized neoantigen targeted mRNA vaccine, in patients with locally advanced unresectable PD-L1 negative non-small cell lung cancer
Van den Eynde Marc & Raes Jeroen
UCLouvain & KU Leuven
598.000 €
Colorectaal
Gerichte behandelingen
Investigating the role and the characteristics of tumor-resident bacteria in colorectal cancer (CRC) metastases
Van Gorp Toon
UZ Leuven
597.452 €
Eierstok
Homologous recombination deficiency (HRD) testing on liquid biopsies in ovarian cancer
Vermeesch Joris
UZ Leuven
493.900 €
Colorectaal
Multi-omics cell-free DNA profiling as a non-invasive predictive and prognostic biomarker for colorectal cancer management
